Jonathan Flint MD http://grandchallenges.ucla.edu/depression/team/ presented his work today in which he gave a compelling talk demonstrating that he has found possible two genetic links to depression. He is a recent UCLA hire in which he joins the UCLA Grand Depression Challenge in which there is a multidisciplinary team working on understanding depression. He began with the familiar statistic that women are twice as likely to get depressed as men, and within that, women have a 20 percent chance of having a depression during their lifetime. He did not quite define depression but in the Q and A, he said that he was using the PHQ-9 which are nine questions to determine the diagnosis, which, of course, makes me suspect. Then he said it causes tremendous disability throughout the world and as such costs the world a lot of money in terms of lost labor. So, he summarizes that depression is common, causes disability and is costly and yet research on depression is minimally funded compared to diseases such as cancer or heart disease. He proceeds to show a negative study by his colleague Ken Kendler which did not demonstrate a gene for depression and so from that he concluded that depression is a heterogeneous disease. Well, that cannot be new information, I think to myself. He went to China where he studied only women, who apparently do not smoke or drink, and through looking at their DNA in their saliva, he could demonstrate that the women with depression had a different genetic makeup than did the controls. At this point I was beginning to be interested. The gene, he continues, impacts the mitochondrial DNA, which is the engine of the cell. He was a wonderful speaker and he did fascinating work, all as a result of new technology that makes sequencing DNA cheap and easy. Like the internet, UCLA could lead the world in this work. I am proud to be a Bruin today!